Research

Research conducted by the Section of Vascular Surgery includes basic, translational and clinical investigations.

Basic research in the Vascular Surgery Research Laboratory involves studies funded by the National Institutes of Health (NIH) that are focused on the molecular and cellular mechanisms of abdominal aortic aneurysms, led by Robert W. Thompson, MD, John A. Curci, MD, and Kathleen G. Raman, MD, MPH. Particular areas of interest are the role of inflammatory mediators, matrix-degrading proteinases, the effect of glycation and smooth muscle cell dysfunction in vascular disease, using both human tissues and experimental animal models. In addition to achieving better understanding of vascular disease mechanisms, the Vascular Surgery Research Laboratory is involved in translational clinical studies aimed at the development and evaluation of novel therapeutic approaches. The section has played a major role in the NIH/NHLBI-Sponsored Specialized Center for Clinically Oriented Research on Metabolic Syndrome and Vascular Disease at Washington University, a program supporting clinical studies to define the influence of metabolic syndrome on aortic aneurysms and a comprehensive core infrastructure for conducting translational clinical studies in patients with aneurysms and other forms of vascular disease.

The vascular surgery faculty are also major contributors and organizers of the Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA3CT). This NIH/NIA-sponsored multicenter randomized clinical trial will determine the effectiveness of doxycycline treatment to slow the growth of small AAAs. Major portions of the scientific underpinnings of this trial have been developed through the work done by the Vascular Surgery Research Laboratory. Dr. Curci runs the Biomarkers Core Laboratory and serves as one of the principal investigators of the N-TA3CT. Dr. Thompson is a clinical site director for enrollment of patients at Washington University into the study.

Clinical research is another active interest in the Section of Vascular Surgery, with ongoing projects on the endovascular treatment of aneurysmal and occlusive arterial disease conducted by by members of the section. The section currently participates in multiple clinical trials of minimally invasive devices in collaboration with industry. Most recently, there has been increased emphasis on patient outcomes research with investigations evaluating the comparative effectiveness of open and endovascular procedures.

Trainees in the section are expected to participate in clinical research efforts. Our trainees have an excellent track record of presentations at both national (Society for Vascular Surgery, Society for Clinical Vascular Surgery, Peripheral Vascular Surgery Society) and regional (Midwestern Vascular Surgical Society) vascular meetings. Recent publications authored by trainees can be found in the Journal of Vascular Surgery, Journal of Endovascular Therapy, Annals of Vascular Surgery and others.

Presentations by Trainees (2009 to current)

  1. Jim J: “Can we treat short aortic necks effectively?”; 34th Annual Spring Meeting, Peripheral Vascular Surgery Society, Denver, CO, June 12, 2009.
  2. Jim J: “Access challenges for thoracic endografting: Selective use of the ascending aorta”; 33rd Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 10, 2009.
  3. Jim J: “EVAR for large aortic necks: A prospective 5 year comparison”; 33rd Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 10, 2009.
  4. Jim J: “Endovascular treatment with a modified Renu Cuff”; 33rd Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 12, 2009.
  5. Jim J: “Complex vascular cases: Branched endograft“; 25th Annual Meeting, St. Louis Vascular Society, St. Louis, MO, October 20, 2009.
  6. Vallabhaneni R; “Complex vascular cases: Aortic dissection and rupture“; 25th Annual Meeting, St. Louis Vascular Society, St. Louis, MO, October 20, 2009.
  7. Jim J: “EVAR for high risk challenging aortic necks: A prospective 5 year comparison”; Annual Meeting, South Florida Society for Vascular Surgery, Palm Beach, FL, October 31, 2009.
  8. Jim J: “Endovascular repair of an iatrogenic thoracic aortic injury during posterior approach spinal surgery”; 20th Annual Winter Meeting, Peripheral Vascular Surgery Society, Vail, CO, January 30, 2010.
  9. Jim J: “Hybrid repair of distal arch and proximal descending thoracic aortic aneurysms: Endovascular elephant trunk completion”; 38th Annual Symposium, Society for Clinical Vascular Surgery, Scottsdale, AZ, April 7, 2010.
  10. Jim J: “Midterm results of a 4F compatible stent in treatment of femoropopliteal atherosclerotic disease”; 38th Annual Symposium, Society for Clinical Vascular Surgery, Scottsdale, AZ, April 7, 2010.
  11. Jim J: “Treatment of a patch aneurysm using a surgeon-modified branched thoracic endograft”; 38th Annual Symposium, Society for Clinical Vascular Surgery, Scottsdale, AZ, April 9, 2010.
  12. Jim J: “Midterm outcomes of the Zenith Renu Ancillary Graft: Results from a post-market registry”; 2010 Vascular Annual Meeting, Society for Vascular Surgery, Boston, MA, June 11, 2010.
  13. Jim J: “Outcome of EVAR for small abdominal aortic aneurysm: Results from a 5 year prospective clinical trial”; 2010 Vascular Annual Meeting, Society for Vascular Surgery, Boston, MA, June 13, 2010.
  14. Duwayri Y: “Positional compression of the axillary artery in the thoracic outlet: the spectrum of lesions in the overhead athlete”; 2010 Vascular Annual Meeting, Society for Vascular Surgery, Boston, MA, June 13, 2010.
  15. Fajardo A: “Acute venous thrombotic events after RFA of the saphenous vein”; 34th Annual Meeting, Midwestern Vascular Surgical Society, Indianapolis, IN, September 9, 2010.
  16. Duwayri Y: “The role of the Kiwi Removable Rigid Dressing System after lower extremity amputation”; 34th Annual Meeting, Midwestern Vascular Surgical Society, Indianapolis, IN, September 9, 2010.
  17. Vallabhaneni R: “Novel treatment to maintain pelvic perfusion during endovascular aortoiliac aneurysm (AIA) repair”; 34th Annual Meeting, Midwestern Vascular Surgical Society, Indianapolis, IN, September 9, 2010.
  18. Aziz A: “Angiographic intervention for type II endoleak with sac expansion: primary failure, secondary benefit”; 34th Annual Meeting, Midwestern Vascular Surgical Society, Indianapolis, IN, September 11, 2010.
  19. Vallabhaneni R: “Early and mid-term outcomes of endovascular and hybrid treatment of bilateral common iliac aneurysms”; 39th Annual Symposium, Society for Clinical Vascular Surgery, Orlando, FL, March 17, 2011.
  20. Caputo F: “Midterm results of management of aortoiliac aneurysms with aortouniiliac devices”; 2011 Vascular Annual Meeting, Society for Vascular Surgery, Chicago, IL, June 17, 2011.
  21. Vallabhaneni R: “Midterm comparison of open versus endovascular repair of pararenal aneurysms”; 2011 Vascular Annual Meeting, Society for Vascular Surgery, Chicago, IL, June 17, 2011.
  22. Sheng G: “Costochondral calcification, osteophytic degeneration and occult first rib fractures in patients with venous thoracic outlet syndrome”; 35th Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 15, 2011.
  23. Caputo F: “Do patients with hostile necks have an increased rate of restenosis after CAS?”; 35th Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 16, 2011.
  24. Caputo F: "Concomitant thoracic aneurysm rupture and acute symptomatic infrarenal aortic occlusion"; 40th Annual Symposium, Society for Clinical Vascular Surgery, Las Vegas, NV, March 17, 2012.
  25. Caputo F: "Supraclavicular decompression for neurogenic thoracic outlet syndrome (NTOS) in pediatric and adult populations: Differential patient characteristics and clinical outcomes"; 2012 Vascular Annual Meeting, Society for Vascular Surgery, National Harbor, MD, June 8, 2012.
  26. Vemuri C: “Effectiveness of isolated pectoralis minor tenotomy in selected patients with neurogenic thoracic outlet syndrome”; 36th Annual Meeting, Midwestern Vascular Surgical Society, Milwaukee, WI, September 7, 2012.
  27. Vemuri, C: “Open abdominal aortic aneurysm repair: A Decade of Experience”; 41st Annual Symposium, Society for Clinical Vascular Surgery, Miami, FL, March 15, 2013.
  28. Jung E: “A rare case of a true mycotic abdominal aortic aneurysm in a patient with a renal transplant”; 37th Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 6, 2013.
  29. Ohman W: “The effect of extremity vascular complications on the outcomes of cardiac support device recipients”; 37th Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 7, 2013. 
  30. Vemuri C: “Post-approval outcomes of juxtarenal aortic aneurysms treated with the Zenith Fenestrated Endovascular Graft”; 37th Annual Meeting, Midwestern Vascular Surgical Society, Chicago, IL, September 7, 2013.

Publications by Trainees (2009 to current)

  1. Wilderman M, Sanchez LA: “Fenestrated grafts or debranching procedures for complex abdominal aortic aneurysms”, Perspect Vasc Surg Endovasc Ther 2009;21(1);13-8. (PMID 19129204)
  2. Thomas B, Sanchez L: “Proximal migration and endoleak: impact of endograft design and deployment techniques.” Semin Vasc Surg 2009;22(3): 201-6. (PMID 19765532)
  3. Jim J, Sanchez LA, Sicard GA, Curci JA, Choi ET, Geraghty PJ, Flye MW, Rubin BG: “Acceptable risk, but small benefit of endovascular aneurysm repair in nonagenarians.”, Ann Vasc Surg 2010;24(4):441-6. Epub 2009 Dec 29. (PMID 20036490)
  4. Jim J, Sanchez LA: “Abdominal aortic aneurysms: endovascular repair”, Mt Sinai J Med 2010;77(3):238-49. (PMID 20506449)
  5. Thomas BG, Sanchez LA, Geraghty PJ, Rubin BG, Money SR, Sicard GA: “A comparative analysis of the outcomes of aortic cuffs and converters for endovascular graft migration”, J Vasc Surg 2010;51(6):1373-80. (PMID 20488319)
  6. Jim J, Rubin BG, Moon MR, Geraghty PJ, Sicard GA, Sanchez LA: “Arterial access for thoracic endograft placement”, Ann Vasc Surg 2010;24(5):640-5. (PMID 20579584)
  7. Jim J, Sicard GA: “Who is unfit for carotid endarterectomy?”, Perspect Vasc Surg Endovasc Ther 2010;22(1):40-6. (PMID 20798077)
  8. Jim J, Sanchez LA, Rubin BG: “Use of a surgeon-modified branched thoracic endograft to preserve an aorto-renal bypass during treatment of an intercostal patch aneurysm”, J Vasc Surg 2010;52(3):730-3. Epub 2010 Jun 15. (PMID 20554424)
  9. Vallabhaneni R, Sanchez LA: “Open techniques for arch vessel reconstruction during thoracic endovascular aneurysm repair (TEVAR)”, J Vasc Surg 2010;52(4 suppl):71S-6S (PMID 20724096).
  10. Jim J, Sanchez LA, Rubin BG, Criado FJ, Fajardo A, Geraghty PJ, Sicard GA: “A 5-Year evaluation using the Talent endovascular graft for endovascular aneurysm repair in short aortic necks”, Ann Vasc Surg 2010;24(7):851-8. (PMID 20831985)
  11. Jung E, Jim J, Rubin BG, Sanchez LA, Choi ET, Sicard GA, Geraghty PJ: “Long term outcomes of endovascular popliteal artery aneurysm repair”, Ann Vasc Surg 2010;24(7):871-5. (PMID 20831988)
  12. Duwayri Y, Jim J, Sanchez LA: “Alternative techniques to abdominal debranching”, Vasc Disease Management 2010;7:E210-3.
  13. Jim J, Rubin BG, Geraghty PJ, Criado FJ, Fajardo A, Sanchez LA: “A 5-Year comparison of EVAR for large and small aortic necks”, J Endovasc Ther 2010;17(5):575-84. (PMID 20939711)
  14. Jim J, Sanchez LA, Geraghty PJ: “Endovascular repair of an intraoperative thoracic aortic injury during all-posterior vertebral column resection surgery”, Ann Vasc Surg 2011;25:132.e1-6. Epub 2010 Aug 30 (PMID 20800435)
  15. Jim J, Rubin BG, Geraghty PJ, Criado FJ, Sanchez LA: “Outcome of endovascular repair of small and large abdominal aortic aneurysms”, Ann Vasc Surg 2011;25:306-14. (PMID 21396566).
  16. Vallabhaneni R, Jim J, Derdeyn CP, Sanchez LA: “Transient cortical blindness after thoracic endovascular aneurysm repair”, J Vasc Surg 2011;53:1405-8. Epub 2011 Jan 26. (PMID 21276688)
  17. Jim J, Rubin BG, Geraghty PJ, Sanchez LA: “Long term outcomes of endovascular aneurysm repair for challenging aortic necks using the Talent endograft”, Vascular 2011;19:132-40. (PMID 21652665)
  18. Duwayri YM, Emery VB, Driskill MR, Earley JA, Wright RW, Paletta GA, Thompson RW: “Positional compression of the axillary artery causing upper extremity thrombosis and embolism in the elite overhead throwing athlete”, J Vasc Surg 2011;53(5):1329-40. (PMID 21276687)
  19. Jim J, Moon MR, Rubin BG, Sicard GA, Sanchez LA: “Hybrid repair of distal aortic arch aneurysms: Endovascular elephant trunk completion”, Ann Vasc Surg 2011;25: 598-604. Epub 2010 Dec 4 (PMID 21131174)
  20. Caputo FJ, Jim J, Sanchez LA: “Alternative technique for endovascular treatment of an abdominal aortic aneurysm with a severely angulated neck”, Vasc Endovascular Surg 2011;45:553-6. Epub 2011 Jun 5. (PMID 21646233).
  21. Duwayri Y, Vallabhaneni R, Kirby JP, Mueller MJ, Volshteyn O, Geraghty PJ, Sicard GA, Curci JA. Early protection and compression of residual limbs may improve and accelerate prosthetic fit: a preliminary study. Ann Vasc Surg 2012:26(2):242-9. Epub 2011 Nov 1. (PMID 22050878)
  22. Sheng GG, Duwayri YM, Emery VB, Wittenberg AM, Moriarty CT, Thompson RW. Costochondral calcification, osteophytic degeneration, and occult first rib fractures in patients with venous thoracic outlet syndrome. J Vasc Surg 2012; 55(5): 1363-9 Epub 2012 Feb 7 (PMID 22322117)
  23. Caputo FJ, Wittenberg AM, Vemuri C, Driskill MR, Earley JA, Rastogi R, Emery VB, Thompson RW: Supraclavicular decompression of neurogenic thoracic outlet syndrome in adolescent and adult populations. J Vasc Surg 2013;57:149-157 (PMID 23127984)
  24. Vemuri C, Wittenberg AM, Caputo FJ, Earley JA, Driskill MR, Rastogi R, Emery VB, Thompson RW: Early effectiveness of isolated pectoralis minor tenotomy in selected patients with neurogenic thoracic outlet syndrome. J Vasc Surg 2013;57:1345-52 (PMID 23375605)