Jun Guo, PhD

Appointment
Assistant Professor of Surgery
Division of Pediatric Surgery
Washington University School of Medicine

Email
guoj@wudosis.wustl.edu

Phone
(314) 454-6022

Fax
(314) 454-2442

Credentials
PhD, Neurobiology, Shanghai Medical University, Shanghai, P. R. China, 2000.

Publications, Most recent
Sheng G, Bernabe KQ, Guo J, Warner BW: Epidermal growth factor receptor mediated proliferation of enterocytes requires p21waf1/cip1 expression. Gastroenterology 131: 153-164, 2006.

Taylor JA, Bernabe KQ, Guo J, Warner BW: Epidermal growth factor receptor–directed enterocyte proliferation does not induce Wnt pathway transcription. J Pediatr Surg 42: 981-986, 2007.

Sheng G, Guo J, Warner BW: Epidermal growth factor receptor signaling modulates apoptosis via p38 MAPK-dependent activation of Bax in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 293: G599-G606, 2007.

Martin CA, Bernabe KQ, Taylor JA, Nair R, Paul RJ, Guo J, Erwin CR, Warner BW: Resection-induced intestinal adaptation and the role of enteric smooth muscle. J Pediatr Surg 43:1011-1017, 2008.

Taylor JA, Martin CA, Nair R, Guo J, Erwin CR, Warner BW: Lessons learned: optimization of the murine small bowel resection model. J Pediatr Surg 43(6):1018-1024, 2008.

Guo J, Longshore S, Nair R, Warner BW: pRb, but not p107 or p130 is required for maintenance of enterocyte quiescence and differentiation in small intestine. J Biol Chem 284: 134-140, 2009.

Longshore SW, Nair R, Perrone EE, Erwin CR, Guo J, Warner BW: p21waf1/cip1 deficiency does not perturb the intestinal crypt stem cell population after massive small bowel resection. J Pediatr Surg 44: 1065-1071, 2009.

Martin CA, Perrone EE, Longshore SW, Toste P, Bitter K, Nair R, Guo J, Erwin CR, Warner BW: Intestinal resection induces angiogenesis within adapting intestinal villi. J Pediatr Surg 44: 1077-1083, 2009.

Wakeman D, Longshore SW, McMellen ME, Santos JA, Guo J, Erwin CR, Warner BW: Extent of small bowel resection does not influence the magnitude of intestinal adaptation in the mouse. J Pediatr Surg 45: 1274-1279, 2010.

McMellen ME, Wakeman D, Erwin CR, Guo J, Warner BW: Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection. Surgery. 2010 Aug;148(2):364-70.

Leinicke JA, Longshore S, Wakeman D, Guo J, Warner BW. Regulation of Retinoblastoma Protein (Rb) by p21 Is Critical for Adaptation to Massive Small Bowel Resection. J Gastrointest Surg. 2012 Jan;16(1):148-55.

Wakeman D, Guo J, Santos JA, Wandu WS, Schneider JE, McMellen ME, Leinicke JA, Erwin CR, Warner BW: p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. Am J Physiol Gastrointest Liver Physiol, 302: G997-G1005, 2012.

Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW: Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection. Am J Physiol Gastrointest Liver Physiol 302: G1143-G1150, 2012.

Wakeman D, Schneider JE, Liu J, Wandu WS, Erwin CR, Guo J, Stappenbeck TS, Warner BW: Deletion of p38-alpha MAPK within enterocytes promotes colon tumorigenesis. Surgery 152: 286-293, 2012.

Related Areas:
Washington University Division of Pediatric Surgery