Christopher R. Erwin, PhD

Appointment
Associate Professor of Surgery
Division of Pediatric Surgery
Washington University School of Medicine

Email
erwinc@WUSTL.EDU

Phone
(314) 747-0050

Fax
(314) 747-0610

Credentials
PhD:
University of Iowa, Iowa City, IA, 1983.

Fellowship: Post Doctoral Fellow, Hormone Research Institute, University of California, San Francisco, CA.

Publications, Most recent
Bernal NP, Stehr W, Coyle R, Erwin CR, Warner BW: EGF receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice. Gastroenterology 130: 412-423, 2006.

Stehr W, Bernal NP, Bernabe KQ, Erwin CR, Warner BW: Absent STAT1 expression perturbs adaptation and apoptosis after massive intestinal resection. J Pediatr Surg 41: 713-718, 2006.

Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW: Combined pharmacotherapy that increases proliferation and decreases apoptosis optimally enhances intestinal adaptation. J Pediatr Surg 41: 719-724, 2006.

Stehr W, Bernal NP, Erwin CR, Bernabe KQ, Guo J, Warner BW: Roles for p21waf1/cip1 and p27kip1 during the adaptation response to massive intestinal resection. Am J Physiol Gastrointest Liver Physiol 290: G933-G941, 2006.

Erwin CR, Jarboe MD, Sartor MA, Medvedovic M, Stringer K, Warner BW, Bates MD: Developmental characteristics of adapting mouse small intestine crypt cells. Gastroenterology 130: 1324-1332, 2006.

Warner BB, Ryan AL, Seeger K, Leonard AC, Erwin C, Warner BW: Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. J Pediatr 358-363, 2007.

Parvadia JK, Keswani SG, Vaikunth S, Maldonado AR, Marwan A, Stehr W, Erwin C, Uzvolgyi E, Warner BW, Yamano S, Taichman N, Crombleholme TM: Role of VEGF in small bowel adaptation after resection: The adaptive response is angiogenesis dependent. Am J Physiol Gastrointest Liver Physiol 293: G591-G598, 2007.

Tantemsapya N, Meinzner-Derr J, Erwin CR, Warner BW: Body composition and metabolic changes associated with massive intestinal resection in mice. J Pediatr Surg 43:14-19, 2008.

Martin CA, Bernabe KQ, Taylor JA, Nair R, Paul RJ, Guo J, Erwin CR, Warner BW: Resection-induced intestinal adaptation and the role of enteric smooth muscle. J Pediatr Surg 43:1011-1017, 2008.

Taylor JA, Martin CA, Nair R, Guo J, Erwin CR, Warner BW: Lessons learned: optimization of the murine small bowel resection model. J Pediatr Surg 43(6):1018-1024, 2008.

Longshore SW, Nair R, Perrone EE, Erwin CR, Guo J, Warner BW: p21waf1/cip1 deficiency does not perturb the intestinal crypt stem cell population after massive small bowel resection. J Pediatr Surg 44: 1065-1071, 2009.

Martin CA, Perrone EE, Longshore SW, Toste P, Bitter K, Nair R, Guo J, Erwin CR, Warner BW: Intestinal resection induces angiogenesis within adapting intestinal villi. J Pediatr Surg 44: 1077-1083, 2009.

Wakeman D, Longshore SW, McMellen ME, Santos JA, Guo J, Erwin CR, Warner BW: Extent of small bowel resection does not influence the magnitude of intestinal adaptation in the mouse. J Pediatr Surg 45: 1274-1279, 2010.

McMellen ME, Wakeman D, Erwin CR, Guo J, Warner BW: Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection. Surgery. 2010 Aug;148(2):364-70.

Bucher BT, McDuffie LA, Shaikh N, Tarr PI, Warner BB, Hamvas A, White FV, Erwin CR, Warner BW. Bacterial DNA content in the intestinal wall from infants with necrotizing enterocolitis. J Pediatr Surg. 2011 Jun;46(6):1029-33.

McDuffie LA, Bucher BT, Erwin CR, Wakeman D, White FV, Warner BW. Intestinal adaptation after small bowel resection in human infants. J Pediatr Surg. 2011 Jun;46(6):1045-51.

Wakeman D, Guo J, Santos JA, Wandu WS, Schneider JE, McMellen ME, Leinicke JA, Erwin CR, Warner BW: p38 MAPK regulates Bax activity and apoptosis in enterocytes at baseline and after intestinal resection. Am J Physiol Gastrointest Liver Physiol, 302: G997-G1005, 2012.

Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW: Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection. Am J Physiol Gastrointest Liver Physiol 302: G1143-G1150, 2012.

Rowland KJ, Yao J, Wang L, Erwin CR, Maslov KI, Wang LV, Warner BW: Immediate alterations in intestinal oxygen saturation and blood flow following massive small bowel resection as measured by photoacoustic microscopy. J Pediatr Surg 47: 1143-1149, 2012.

Wakeman D, Schneider JE, Liu J, Wandu WS, Erwin CR, Guo J, Stappenbeck TS, Warner BW: Deletion of p38-alpha MAPK within enterocytes promotes colon tumorigenesis. Surgery 152: 286-293, 2012.

Rowland KJ, McMellen ME, Erwin CR, Wandu WS, Warner BW: Enterocyte expression of epidermal growth factor receptor is not required for intestinal adaptation in response to massive small bowel resection. J Pediatr Surg 47: 1748-1753, 2012.

Research
Study adaptation after small bowel resection with special interest in the effects of EGF using a molecular biology approach.

Recent Presentations
Longshore SW, Nair R, Perrone EE, Erwin CR, Guo J, Warner BW: “p21waf1/cip1 deficiency does not perturb the intestinal crypt stem cell population after massive small bowel resection.” Presented at the American Academy of Pediatrics - Surgical Section, October 10-14, 2008. Boston, MA

Martin CA, Perrone EE, Longshore SW, Toste P, Bitter K, Nair R, Guo J, Erwin CR, Warner BW: Intestinal resection induces angiogenesis within adapting intestinal villi. Presented at the American Academy of Pediatrics - Surgical Section, October 10-14, 2008. Boston, MA.

Wakeman DS, Longshore SW, Guo J, Erwin CR, Warner BW: “Extent of small bowel resection does not influence the magnitude of intestinal adaptation in the mouse.” Presented at the American Academy of Pediatrics - Surgical Section, October 16-18, 2009; Washington DC.

McMellen ME, Wakeman D, Erwin C, Guo J, Warner BW: “EGFR-directed CXCL5 expression Is involved in villus angiogenesis following small bowel resection.” Presented at the 5th Annual Academic Surgical Congress, February 3-5, 2010; San Antonio TX.

Wakeman DS, Santos JA, Guo J, Erwin CR, Warner BW: Inducible, intestine-specific deletion of p38alpha MAPK perturbs normal enterocyte turnover. Presented at the 5th Annual Academic Surgical Congress, February 3-5, 2010; San Antonio TX.

Bucher BT, McDuffie LA, Shaikh N, Warner BB, Hamvas A, White FV, Erwin CR, Warner BW: Bacterial DNA load in the intestinal wall from infants with necrotizing enterocolitis. Presented at the American Academy of Pediatrics - Section on Surgery, October 2-5, 2010; San Francisco, CA.

McDuffie LA, Bucher BT, Erwin CR, Wakeman DS, White FV, Warner BW: Intestinal adaptation following small bowel resection in human infants. Presented at the American Academy of Pediatrics - Section on Surgery, October 2-5, 2010; San Francisco, CA.

Wakeman D, Guo J, Santos JA, Schneider J, Leinicke J, Rowland KJ, Erwin CR, Warner BW: Intestinal resection-induced enterocyte apoptosis Is mediated by p38α MAPK-directed activation of Bax. Presented at the Society for Surgery of the Alimentary Tract, Digestive Disease Week, May 7 - 11, 2011, Chicago IL.

Hitch MC, Leinicke J, Guo J, Erwin CR, Heuckeroth RO, Warner BW: Genetically-altered enteric nervous system results in an amplified adaptation response to massive small bowel resection. Presented at the Society for Surgery of the Alimentary Tract, Digestive Disease Week, May 7 - 11, 2011, Chicago IL.

Related Areas:
Washington University Division of Pediatric Surgery