The laboratory of Jeffrey F. Moley, MD, is studying the molecular genetics of cancer, specifically endocrine cancers and sarcomas. On the basis of their laboratory findings, they have designed and carried out diagnostic and therapeutic clinical trials with an interest in developing novel approaches to treatment of these tumors. The laboratory has also identified specific patterns of glucose transporter expression in cancer. The lab has cloned a novel member of the glucose transporter family, and its function and role in cancer are being studied. The laboratory is involved in collaborative studies to evaluate modifier genes in the development of the multiple endocrine neoplasia syndromes. Researchers are carrying out prospective, therapeutic clinical trials of tyrosine kinase inhibitors in the treatment of metastatic thyroid cancer.
The research interests of Julie A. Margenthaler, MD, include the investigation of minimally invasive techniques using molecular analysis to stage the axilla in breast cancer patients. She is also very involved in the study of young women (<40 years) with breast cancer in order to identify the unique tumor characteristics in these patients and the novel hereditary markers present in their genome. Other interests include the investigation of the role of surgery in patients with metastatic breast cancer and the role of sentinel lymph node biopsy in multicentric breast cancers. Dr. Margenthaler is an investigator for the Program for the Elimination of Cancer Disparities and is currently investigating the barriers to early, effective breast cancer diagnosis and treatment in the underserved populations of St. Louis City.
The research interests of Amy E. Cyr, MD, are in the area of breast cancer staging, specifically evaluating non-surgical alternatives to axillary staging. Other interests include evaluating breast cancer patient decision-making, high-risk breast lesions, and effective use of health-care dollars.
The research interests of Bruce L. Hall, MD, PhD, MBA, span quality measurement, quality improvement, and coordination of care and providers across health systems. A key part of this work focuses on resource utilization and sustainability of health care. Dr. Hall is consulting director of the National Surgical Quality Improvement Program of the American College of Surgeons (ACS-NSQIP) and medical director of the NSQIP-Pediatric program. He also serves as a champion for implementation of NSQIP at BJC hospitals. Dr. Hall is vice president of Patient Outcomes for the BJC Healthcare system.