Cardiothoracic Laboratories

The Cardiothoracic Surgery (CTS) Research Laboratory is a joint laboratory of all the general thoracic and cardiovascular surgeons. The mission of the laboratory is: 1) to train future cardiothoracic surgeons in the basic sciences and methodology of research in order for them to become independent physician–scientists; and 2) to solve the clinical problems that arise in cardiothoracic surgery by understanding the basic physiology and pathology of the underlying problems. In the last 10 years, we have trained 92 fellows in our laboratory. Our research-training program allows us to support research fellows both from within Washington University and from other institutions.

The following is a partial list of ongoing research projects of the CTS faculty.

  • Lung Preservation for Transplantation (Dr. Patterson)
  • IL-8 Inhibition Study (Repertaxin) (Dr. Patterson)
  • Surgical Treatment of Cardiac Arrhythmias (Dr. Damiano)
  • Dual-Phase Small Caliber Vascular Prosthesis (Dr. Damiano)
  • The Learning Process in Robotic Surgery (Dr. Damiano)
  • Development of Linear Lesion Device (Dr. Damiano)
  • Left Ventricular Remodeling in Aortic Insufficiency (Dr. Pasque)
  • 3D Myocardial Strain Vectors in Ischemic Heart Disease (Dr. Pasque)
  • Analysis Software to Characterize Myocardial Mechanics (PI: Dr. Pasque)
  • Left Ventricular Remodeling in Aortic Insufficiency (Dr. Cupps)
  • 3D Myocardial Strain Vectors in Ischemic Heart Disease (Dr. Cupps)
  • Pathophysiology and Treatment of Pulmonary Hypertension (Dr. Moon)
  • Mechanisms Underlying Cardioplegia-Induced Cell Swelling and Myocardial Stunning (Dr. Lawton)
  • Surgical Treatment of Cardiac Arrhythmias (Dr. Schuessler)
  • Regulation of Myocardial Gap Junctions (Dr. Schuessler)
  • Structural and Electrical Remodeling of Cx45 (Dr. Schuessler)
  • Cx43 in a Genetic Model of Altered Myocardial Conduction (Dr. Schuessler)
  • Membrane-Mediated Alterations in Diabetes (Dr. Schuessler)
  • Surgical Treatment of Cardiac Arrhythmias

The research is supported by NIH, NIST, private foundations, corporate and division funding.

This is a partial list of funding sources:

  • T32 Basic Science Research Training-Cardiopulmonary Surgery. PI: Patterson
  • F32 Individual NRSA. PI: Melby and Voeller
  • R01 Regulation of Myocardial Gap Junctions $11,000. Co-PI: Schuessler
  • R01 Cx43 in a Genetic Model of Altered Myocardial Conduction. Co-PI: Schuessler
  • NIH SBIR Analysis Software to Characterize Myocardial Mechanics. PI: Pasque
  • NIST SBIR Dual-Phase Small Caliber Vascular Prosthesis. PI: Damiano
  • Barnes-Jewish Hospital Foundation, Mechanisms of postoperative arrhythmias in patients underoing thoracic surgical procedures (Schuessler)
  • Atricure Inc. PI: Damiano
  • Dompe. PI: Patterson

The laboratory has a full-time staff of 10 people who have a range of skills. These include trained animal technicians, molecular biology technicians, computer and electronic engineering staff, and administrative support staff. These individuals are not only involved in research, but have a primary task of training students and research fellows. The CTS Research Laboratory also has a close collaborative relationship with the laboratory of Dr. Thalachallour Mohanakumar. Details of his research can be found on his faculty page

If you are interested in learning more about the opportunities for research training in the CTS Research Laboratory, contact Richard B. Schuessler, Ph.D., director, Cardiothoracic Research Laboratory, at
schuesslerr@wudosis.wustl.edu or call 314-362-8300.

General Thoracic Surgery

Traves D. Crabtree, MD

  • Associate Professor of Surgery

Patient #:(314) 362-8089

Alexander S. Krupnick, MD

  • Associate Professor of Surgery

Patient #:(314) 362-9181

G. Alexander Patterson, MD

  • Joseph Bancroft Professor of Surgery

Patient #:(314) 362-6025

Daniel Kreisel, MD, PhD

  • Professor of Surgery, Pathology & Immunology

Patient #:(314) 362-6021

Bryan Fitch Meyers, MD, MPH

  • Patrick and Joy Williamson Professor of Surgery
  • Chief, Section of Thoracic Surgery

Patient #:(314) 362-8598

Varun Puri, MD, MSCI

  • Assistant Professor of Surgery

Patient #:636-916-7123

Cardiac Surgery

Keki R. Balsara, MD

Assistant Professor, Surgery

Patient #:(314) 362-9181

Ralph James Damiano, Jr., MD

  • Evarts A. Graham Professor of Surgery
  • Chief, Division of Cardiothoracic Surgery

Patient #:(314) 362-7327 or 1-888-800-9484

Hersh S. Maniar, MD

  • Associate Professor of Surgery

Patient #:(314) 362-7431 or 1-888-800-9484

Michael K. Pasque, MD

  • Professor of Surgery

Patient #:(314) 362-6237 or 1-888-800-9484

Scott C. Silvestry, M.D.

  • Associate Professor of Surgery

Patient #:314-362-6182

Spencer J. Melby, MD

  • Assistant Professor of Surgery

Patient #:(314) 362-7260

Jennifer S. Lawton, MD, FACS

  • Professor of Surgery

Patient #:(314) 362-2821 or 1-888-800-9484

Marc R. Moon, MD

  • John M. Shoenberg Professor, Surgery
  • Chief, Section of Cardiac Surgery
  • Program Director, Thoracic Surgery Residency Program

Patient #:(314) 362-0993

Stefano Schena, MD, PhD

  • Assistant Professor of Surgery

Sees patients at Christian Hospital

Patient #:(314) 355-3003

Pediatric Cardiothoracic Surgery

Umar Sekou-Toure Boston, MD

  • Associate Professor of Surgery

Patient #:314-454-6165

Peter B. Manning, MD

Professor of Surgery

Patient #:(314) 454-6165

Pirooz Eghtesady, MD, PhD

  • Chief, Section of Pediatric Cardiothoracic Surgery
  • Cardiothoracic Surgeon-in-Chief,  St. Louis Children's Hospital

Patient #:(314) 454-6165