Research

From left, Daniel Kreisel, MD, PhD, Andrew Gelman, PhD, and Alexander Krupnick, MD, have established a large combined laboratory to investigate lung immunology and cancer from multiple angles.Faculty research within the Division of Cardiothoracic Surgery encompasses a wide range of interests including transplant immunology, lung cancer, lung transplantation, cardiac arrhythmia surgery, cardiac electrophysiology, myocardial preservation and cardiac mechanics. The research is supported by multiple NIH R01 grants, a T32 training grant, a K08 grant, individual National Research Service Awards, American Heart Association grants, American Society of Transplant Surgeons grants and Barnes-Jewish Hospital Foundation grants. Industry parternships provide additional funding. The Division of Cardiothoracic Surgery also supports projects with funding.

In recent years, the division has experienced significant growth in its faculty and research programs. The laboratory has collaborative research projects with faculty in cardiology, pulmonary medicine, pathology, cell and molecular biology, neuroscience, biomedical engineering and mechanical engineering. A joint optical mapping facility shared by pathology, cell and molecular biology, medicine and neurology is located in the cardiothoracic surgery laboratory. The sharing of equipment and expertise not only facilitates research, but also provides a broader research training experience for the research fellows.

All cardiothoracic surgery research facilities – about 6,500 square feet in area – are located within the Clinical Sciences Research Building.

National Institutes of Health —
Active NIH Grant Support with Cardiothoracic Surgery as Principal Investigator

Ralph J. Damiano, Jr., Program Director
Basic Science Research Training: Cardiopulmonary Surgery
NIH Training Grant T32 HL007776 Dates: 07/01/1994-06/30/2016

Ralph J. Damiano, Jr., P.I.
Surgical Treatment of Cardiac Arrhythmias
NIH R0I HL032257 Dates: 8/8/1983 – 12/31/2013

Pirooz Eghtesady, P.I.
Developing an animal model of HLHS: role of immune mediated injury
NIH//NHLBI R21HL104391-01A1 Dates: 7/25/2011 – 5/31/2013

Pirooz Eghtesady, P.I.
Hypoplastic Left Heart Syndrome: Expression of Rheumatic Heart Disease in the Fetus?
NIH/NHLBI R01 HL098634-01 Dates: 05/15/2011 – 12/31/2014

Andrew E. Gelman, P.I.
Refanalin for Lung Preservation and Transplantation
NIH R44 HL080806 Dates: 5/1/11 – 01/31/2012

Andrew E. Gelman, P.I.
Apyrase to Treat Ischemia/Reperfusion Injury during Lung Transplantation
NIH 2R44 HL087456-02 Dates: 3/31/2008 – 2/28/12

Daniel Kreisel and Andrew Gelman, P,I.
The Role of Ischemia Reperfusion Injury in Lung Allograft Rejection
NIH R0I HL094601 Date: 9/2/2009 – 7/31/2014

A. Sasha Krupnick, P.I.
The Role of Non-Hematopoietic Cells in Tumor Tolerance Induction
NIH K08 CAI3I097 Dates: 9/11/2008 – 8/31/2013

Jennifer S. Lawton, P.I.
Exploitation of the KATP Charmel Opener Diazoxide During Cardiac Surgery
NIH R0I HL098182 I Dates: 4/1/2010 – 3/31/2015

Thalachallour Mohanakumar, P.I.
Alloantibodies to Mhc Induces Autoimmunity and Obliterative Airway Disease (Oad)
NIH R01 HL092514 Dates: 8/6/2009 – 5/31/2013

Marc Moon, P.I.
"Right Heart Funclion in Pulmonary Hypertension wilh Beta-Agonist and Atrial Shunt"
NIH R0I HL092088 Dates: 4/1/2008 – 3/31/2013

Richard B. Schuessler, P.I.
"The Role of lnflammation In Postoperative Atrial Fibrillation"
NIH R0J HL085113 Dates:9/30/2007 – 6/30/2012

Volunteer for Health