Dr. Lawton specializes in cardiac surgery, coronary artery bypass graft (CABG) (on- and off-pump), beating heart surgery and valve surgery.
Other areas of clinical interest include coronary artery revascularization, valve repair and replacement, minimally invasive cardiac surgery, myocardial preservation, and women and heart disease
American Heart Association Grant-in-Aid
7/1/2009 - 6/30/2011
($71,500/Yr. for 2 years)
Mechanisms of the Cardioprotective KATP Channel
NIH RO1HL098182-01A1 Principal Investigator
4/1/2010 – 3/31/2015
($175,000/Yr. for 5 years)
Exploitation of the KATP Channel Opener Diazoxide During Cardiac Surgery
Myocardial protection, hyperpolarizing cardioplegia, ATP-sensitive potassium channels, and myocyte volume changes during cardioplegic arrest.
Lawton JS. Sex and gender differences in coronary artery disease. Semin Thorac Cardiovasc Surg. 2011 Summer;23(2):126-30.
Sellitto AD, Al-Dadah AS, Schuessler RB, Nichols CG, Lawton JS. An open sarcolemmal adenosine triphosphate-sensitive potassium channel is necessary for detrimental myocyte swelling secondary to stress. Circulation. 2011 Sep 13;124(11 Suppl):S70-4.
Lawton JS, Cupps BP, Knutsen AK, Ma N, Brady BD, Reynolds LM, Pasque MK. Magnetic resonance imaging detects significant sex differences in human myocardial strain. Biomed Eng Online. 2011 Aug 22;10:76.
Zhang HX, Akrouh A, Kurata HT, Remedi MS, Lawton JS, Nichols CG. HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels. J Mol Cell Cardiol. 2011 Mar;50(3):552-60.
Sellitto AD, Maffit SK, Al-Dadah AS, Zhang H, Schuessler RB, Nichols CG, Lawton JS. Diazoxide maintenance of myocyte volume and contractility during stress: evidence for a non-sarcolemmal K(ATP) channel location. J Thorac Cardiovasc Surg. 2010 Nov;140(5):1153-9.
Cupps BP, Taggar AK, Reynolds LM, Lawton JS, Pasque MK. Regional myocardial contractile function: multiparametric strain mapping. Interact Cardiovasc Thorac Surg. 2010 Jun;10(6):953-7.
Aziz A, Lee AM, Pasque MK, Lawton JS, Moazami N, Damiano RJ Jr, Moon MR. Evaluation of revascularization subtypes in octogenarians undergoing coronary artery bypass grafting. Circulation. 2009 Sep 15;120(11 Suppl):S65-9.
Lawton JS, Moazami N, Pasque MK, Moon MR, Damiano RJ Jr. Early stenosis of Medtronic Mosaic porcine valves in the aortic position. J Thorac Cardiovasc Surg. 2009 Jun;137(6):1556-7.
Moon MR, Lawton JS, Moazami N, Munfakh NA, Pasque MK, Damiano RJ Jr. POINT: Prosthesis-patient mismatch does not affect survival for patients greater than 70 years of age undergoing bioprosthetic aortic valve replacement. J Thorac Cardiovasc Surg. 2009 Feb;137(2):278-83.
Moraca RJ, Moon MR, Lawton JS, Guthrie TJ, Aubuchon KA, Moazami N, Pasque MK, Damiano RJ Jr. Outcomes of tricuspid valve repair and replacement: a propensity analysis. Ann Thorac Surg. 2009 Jan;87(1):83-8; discussion 88-9.
Crabtree TD, Bailey MS, Moon MR, Munfakh N, Pasque MK, Lawton JS, Moazami N, Aubuchon KA, Al-Dadah AS, Damiano RJ Jr. Recurrent mitral regurgitation and risk factors for early and late mortality after mitral valve repair for functional ischemic mitral regurgitation. Ann Thorac Surg. 2008 May;85(5):1537-42; discussion 1542-3.
Al-Dadah AS, Voeller RK, Schuessler RB, Damiano RJ Jr, Lawton JS. Maintenance of myocyte volume homeostasis during stress by diazoxide is cardioprotective. Annals of Thoracic Surgery. 2007;84(3):857-862.
Schena S, Wildes T, Beardslee MA, Lasala JM, Damiano RJ Jr, Lawton JS. Successful management of unremitting spasm of the nongrafted right coronary artery after off-pump coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery. 2007;133(6):1649-1650
Kaiser SP, Melby SJ, Zierer A, Schuessler RB, Moon MR, Moazami N, Pasque MK, Huddleston C, Damiano RJ Jr, Lawton JS. Long-term outcomes in valve replacement surgery for infective endocarditis. Annals of Thoracic Surgery. 2007;83(1):30-35.
Lawton JS, Moon MR, Curci JA, Rubin BG, Smith TW, Gleva MJ, Damiano RJ Jr. Management of arterial injuries caused by laser extraction of indwelling venous pacemaker and defibrillator leads. Pacing and Clinical Electrophysiology. 2006;29(8):917-920.
Pub Med page for Jennifer S. Lawton, M.D., F.A.C.S.
Lawton JS. Complications of Extracorporeal Circulation. In: Complications in Surgery.
Philadelphia: Lippincott, Williams & wilkins; 2006:277-285.