physician photo

Akinobu Itoh, MD, PhD

  • Instructor, Surgery

Medical School

MD, Tohoku University School of Medicine, Sendai, Japan, 1998

Graduate School

PhD, Tohoku University School of Medicine, Sendai, Japan, 2010

Post Doctoral Education

Resident, General Surgery, NTT Medical Center Tokyo, Tokyo, Japan, 1998-2000

Resident, Cardiovascular Surgery, NTT Medical Center Tokyo, Tokyo, Japan, 2000-2002

Senior Resident, Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan, 2002-2005

Carl and Leah McConnell Cardiovascular Surgical Research Fellow, Stanford University, 2005-2008

Clinical Fellow, Cardiovascular Surgery, University of Toronto, St. Michael's Hospital, Toronto, Ontario, Canada, 2009-2010

Clinical Fellow, Transplant/Heart Failure Surgery, University of Toronto, Toronto General Hospital, Toronto, Ontario, Canada, 2011

Clinical Fellow, Transplant/Heart Failure Surgery, Washington University School of Medicine, 2012

Board Certifications

Japanese Board of Surgery -- Certified
Japanese Board of Cardiovascular Surgery -- Certified

Clinical Interests

Heart valve repair/replacement, aortic root surgery, coronary artery bypass (bilateral IMA and off-pump surgery), heart transplantation, mechanical assist device (LVAD/ECMO) for heart failure, pre/post operative patient care

Research Interests

Clinical results in patients with LVAD, mitral valve dynamics after mitral valve repair, myocardial strain and structural alteration in heart disease.

Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Center for Advanced Medicine
4921 Parkview Place, Suite A, 8th Floor 
St. Louis, MO 63110
Office phone: 314-362-8008 or 1-888-800-9484
Fax: 314-747-4216

Contact Information

Washington University School of Medicine
Department of Surgery, Division of Cardiothoracic Surgery
CB 8234, 660 S. Euclid Ave.
St. Louis, MO 63110

Selected Publications

Itoh A, Stephens EH, Ennis DB, Carlhall CJ, Bothe W, Nguyen TC, Swanson JC, Miller DC, Ingels NB Jr. Contribution of myocardium overlying the anterolateral papillary muscle to left ventricular deformation. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H180-7. Epub 2011 Oct 28.

Itoh A, Fischbein M, Arata K, Miller DC. "Peninsula-style" transverse aortic arch replacement in patients with bicuspid aortic valve. Ann Thorac Surg. 2010 Oct;90(4):1369-71.

Kung GL, Nguyen TC, Itoh A, Skare S, Ingels NB Jr, Miller DC, Ennis DB. The presence of two local myocardial sheet populations confirmed by diffusion tensor MRI and histological validation. J Magn Reson Imaging. 2011 Nov;34(5):1080-91. Epub 2011 Sep 19.

Swanson JC, Krishnamurthy G, Itoh A, Kvitting JP, Bothe W, Craig Miller D, Ingels NB Jr. Multiple mitral leaflet contractile systems in the beating heart. J Biomech. 2011 Apr 29;44(7):1328-33. Epub 2011 Feb 2.

Krishnamurthy G, Itoh A, Swanson JC, Miller DC, Ingels NB Jr. Transient stiffening of mitral valve leaflets in the beating heart. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2221-5. Epub 2010 Apr 16.

Itoh A, Ennis DB, Bothe W, Swanson JC, Krishnamurthy G, Nguyen TC, Ingels NB Jr, Miller DC. Mitral annular hinge motion contribution to changes in mitral septal-lateral dimension and annular area. J Thorac Cardiovasc Surg. 2009 Nov;138(5):1090-9. Epub 2009 Sep 11

Bothe W, Ennis DB, Carlhäll CJ, Nguyen TC, Timek TA, Lai DT, Itoh A, Ingels NB Jr, Miller DC. Regional mitral leaflet opening during acute ischemic mitral regurgitation. J Heart Valve Dis. 2009 Nov;18(6):586-96; discussion 597.

Swanson JC, Davis LR, Arata K, Briones EP, Bothe W, Itoh A, Ingels NB, Miller DC. Characterization of mitral valve anterior leaflet perfusion patterns. J Heart Valve Dis. 2009 Sep;18(5):488-95.

Ennis DB, Nguyen TC, Itoh A, Bothe W, Liang DH, Ingels NB, Miller DC. Reduced systolic torsion in chronic "pure" mitral regurgitation. Circ Cardiovasc Imaging. 2009 Mar;2(2):85-92. Epub 2009 Jan 22.

Krishnamurthy G, Itoh A, Swanson JC, Bothe W, Karlsson M, Kuhl E, Craig Miller D, Ingels NB Jr. Regional stiffening of the mitral valve anterior leaflet in the beating ovine heart. J Biomech. 2009 Dec 11;42(16):2697-701. Epub 2009 Sep 18.

Bothe W, Chang PA, Swanson JC, Itoh A, Arata K, Ingels NB, Miller DC. Releasable annuloplasty ring insertion--a novel experimental implantation model. Eur J Cardiothorac Surg. 2009 Nov;36(5):830-2.  Epub 2009 Jul 30.

Krishnamurthy G, Itoh A, Bothe W, Swanson JC, Kuhl E, Karlsson M, Craig Miller D, Ingels NB Jr. Stress-strain behavior of mitral valve leaflets in the beating ovine heart. J Biomech. 2009 Aug 25;42(12):1909-16.  Epub 2009 Jun 16.

Bothe W, Nguyen TC, Roberts ME, Timek TA, Itoh A, Ingels NB Jr, Miller DC. Presystolic mitral annular septal-lateral shortening is independent from left atrial and left ventricular contraction during acute volume depletion. Eur J Cardiothorac Surg. 2009 Aug;36(2):236-42; discussion 242-3. Epub 2009 Apr 25.

Itoh A, Krishnamurthy G, Swanson JC, Ennis DB, Bothe W, Kuhl E, Karlsson M, Davis LR, Miller DC, Ingels NB Jr.Active stiffening of mitral valve leaflets in the beating heart. Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1766-73. Epub 2009 Apr 10.

Stephens EH, Nguyen TC, Itoh A, Ingels NB Jr, Miller DC, Grande-Allen KJ. The effects of mitral regurgitation alone are sufficient for leaflet remodeling. Circulation. 2008 Sep 30;118(14 Suppl):S243-9.

Pub Med page for Akinobu Itoh, MD, PhD