physician photo

Isaiah R. Turnbull, MD, PhD

Assistant Professor of Surgery

Medical School

MD, Washington University School of Medicine, St. Louis, MO, 2008

Graduate School

PhD, Washington University School of Medicine, St. Louis, MO, 2008

MA, Washington Univeristy School of Medicine, St. Louis, MO, 2008

Post Doctoral Education

Intern in General Surgery, Washington University School of Medicine, St. Louis, MO, 2009

Resident in General Surgery, Washington University School of Medicine, St. Louis, MO, 2012

Chief Resdient in General Surgery, Washington University School of Medicine, St. Louis, MO, 2013

Fellowship in Surgical Critical Care, Department of Surgery, Washington University School of Medicine, St. Louis, MO, 2014

Board Certifications

General Surgery

Research Interests

Principal Investigator. "American College of Surgeons C. James Carrico, MD, FACS, Faculty Research Fellowship for the Study of Trauma and Critical Care," American College of Surgeons, 2014

Hospital Affiliations

Barnes-Jewish Hospital

Selected Publications

McConnell KW, McDunn JE, Clark AT, Dunne WM, Dixon DJ, Turnbull IR, Dipasco PJ, Osberghaus WF, Sherman B, Martin JR, Walter MJ, Cobb JP, Buchman RG, Hotchkiss RS, Coopersmith CM. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit. Care Med. 2010; 38: 223-41.

Otero K, Turnbull IR, Poliani PL, Vermi W, Cerutti E, Aoshi T, Tassi I, Takai T, Stanley SL, Miller M, Shaw AS, Colonna M. Macrophage colony-stimulating factors induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. Nat. Immunol. 2009; 10: 734-43.

Turnbull IR, Clark AT, Stromberg PE, Dixon DJ, Woolsey CA, Davis CG, Hotchkiss RS, Buchman TG, Coopersmith, CM. Effects of aging on the immunopathological response to sepsis. Crit. Care Med. 2009; 37: 1018-1023.

Stromberb PE, Woolsey CA, Clark AT, Clark JA, Turnbull IR, McConnell KW, Chang KC, Chung CS, Ayala A, Buchman TG, Hotchkiss RS, Coopersmith CM. CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis. FASEB J. 2009; 23: 1817-25.

Tassi I, Cella M, Gilfillan S, Turnbull I, Diacovo TG, Penninger JM, Colonna M. p110 gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity. 2007; 27: 214-27.

Turnbull IR, Gilfillan S, Cella M, Aoshi T, Miller M, Piccio L, Hernandez M, Colonna M. Cutting edge: TREM-2 attenuates macrophage activation. J. Immunol. 2006; 117: 3520-4.

McDunn JE, Turnbull IR, Polpitiya AD, Tong A, MacMillan SK, Osborne DF, Hotchkiss RS, Colonna M, Cobb JP. Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. J. Am. Coll. Surg. 2006; 203: 365-75.

Khor B, Bredemeyer AL, Huang CY, Turnbull IR, Evans R, Maggi LB Jr., White JM, Walker LM, Carnes K, Hess RA, Sleckman BP. Proteasome activator PA200 is required for normal spermatogenesis. Mol. Cell. Biol. 2006; 26: 2999-3007.

Husain KD, Stromberg PE, Woolsey CA, Turnbull IR, Dunne WM, Javadi P, Buchman TG, Karl IE, Hotchkiss RS, Coopersmith CM. Mechanisms of decreases intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit. Care Med. 2005; 33: 2350-7. 

Turnbull IR, McDunn JE, Takai T, Townsend RR, Cobb JP, Colonna M. DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis. J. Exp. Med. 2005; 202: 363-9.

Javadi P, Buchman TG, Stromberg PE, Turnbull IR, Vyas D, Hotchkiss RS, Karl IE, Coopersmith CM. Iron dysregulation combined with aging prevents sepsis-induced apoptosis. J. Surg. Res. 2005; 128: 37-44.

Turnbull IR, Buchman TG, Javadi P, Woolsey CA, Hotchkiss RS, Karl IE, Coopersmith CM. Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium. Shock. 2004; 22: 364-8.

Javadi P, Buchman TG, Stromberg PE, Husain KD, Dunne WM, Woolsey CA, Turnbull IR, Hotchkiss RS, Karl IE, Coopersmith CM. High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit. Care Med. 2004; 32: 1178-85.

Turnbull IR, Javadi P, Buchman TG, Hotchkiss RS, Karl IE, Coopersmith CM. Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock. 2004; 21: 121-5.

Wizorek JJ, Turnbull IR, Buchman TG. Iron overload before cecal ligation and puncture increases mortality. Shock. 2003; 20: 52-5.

Pub Med Page for Isaiah R. Turnbull, MD, PhD

 

Books

 

Chapters

Turnbull I, Lu Y, Verkman A, Skach W. Biogenesis and folding of Aquaporin water channels in the endoplasmic reticulum. In Molecular Biology and Physiology of Water and Solute Trasport: Fundamental and Applied Aspects. (S Hohmann, editor), Kluwer Academic/Plenum Publishers, 2000.