physician photo

Paul F. Austin, MD

  • Professor of Surgery
  • Director, Pediatric Urology Research

Medical School

University of Kentucky, College of Medicine, Lexington, Kentucky, 1991

Post Doctoral Education

Residency: General Surgery, University of South Florida, College of Medicine, Tampa, Florida, 1993

Residency: Urology, University of South Florida, College of Medicine, Tampa, Florida, 1997

Fellowship: Pediatric Urology, Indiana University School of Medicine, Indianapolis, Indiana, 1999

Board Certifications

Urology—Certified

Honors and Awards

2011, Listed in Best Doctors in America, (Best Doctors, Inc.)

2007, Clinical Research Prize - 2nd Place, American Academy Pediatrics Section on Urology

Best Case Presentation, American Association of Pediatric Urologists Annual Meeting, Fort Lauderdale, FL, 2006

Society of Pediatric Urology Research Award Recipient, 2006

Best Poster Presentations, 5th World Congress of Urological Research, London, England, 2003.

Travel Award, Society for Basic Urologic Research Symposium, Tucson, AZ, 2002.

Clinical Interests

Pediatric urological surgery, congenital abnormalities of the genitourinary tract.

Research Interests

NIH, NIDDK, K08 DK054864
Austin (PI) 8/15/03-6/30/08
Regulation of Bladder Smooth Muscle Hyperplasia
The goal of this study is to delineate the signal transduction pathways that regulate the bladder hyperplastic response to bladder outlet obstruction in an attempt to find new targets for intervention to prevent the pathologic change in bladder compliance that occurs with either anatomic or functional bladder outlet obstruction.
Role: PI

Phase II Study Clinical Research Trial
Austin (PI) 04/06-12/08
Boehringer Ingelheim
An Uncontrolled, Open-Label, Titration, Long-Term Safety (up to 12 months) and Efficacy Study of Tamsulosin Hydrochloride in Children with Neuropathic Bladder, with a Randomized Pharmacokinetic Sub-Study Investigating Low, Medium and High Dose Ranges
Role: PI

Society of Pediatric Urology Research Grant
Austin (PI) 7/1/06-6/30/08
A Randomized, Placebo-Controlled Study Examining the Efficacy of Oral Midazolam in Reducing Anxiety in Children Undergoing Voiding Cystourethrogram.
The objective of this research proposal is to validate the common practice of administering oral midazolam in children prior to voiding cystourethrography (VCUG).
Role: PI

American Association of Pediatric Urology Research Grant
Austin (PI) 3/1/07-2/28/08
The Translational Significance of Cell Cycle Determinants of Bladder Smooth Muscle Hyperplasia
The purpose of this study is to translate and provide clinical relevance to the molecular findings of cell cycle regulators of bladder smooth muscle proliferation.
Role: PI

Midwest Stone Institute Grant
Austin (PI) 3/1/07-2/28-08
The Regulation and Role of BMP-7 in Obstructive Uropathy
The objective of this study is to identify the mechanism by which BMP-7 production is regulated in normal kidney tissue and in obstructive uropathy-damaged kidney tissue.
Role: PI

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital
Missouri Baptist Hospital

Patients Seen At

St. Louis Children's Hospital
One Children's Place, Suite A, Second Floor
St. Louis, MO 63110
(314) 454-6034
Fax: (314) 454-2876

Barnes-Jewish West County Hospital
Professional Office Building #1
1040 North Mason Road, Suite 122
St. Louis, MO 63141
(314) 996-8060

Selected Publications

Coplen DE, Austin PF, Yan Y, Blanco VM, Dicke JM. The magnitude of fetal renal pelvic dilatation can identify obstructive postnatal hydronephrosis, and direct postnatal evaluation and management. Journal of Urology. 2006;176(2):724-727; discussion 727.

Austin PF, Cook BL, Niederhoff RA, Manson SR, Coplen DE, Weintraub SJ. Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin. Journal of Urology. 2004;172(4 Pt 2):1662-1665; discussion 1666.

Coplen DE, Austin PF. Outcome analysis of prenatally detected ureteroceles associated with multicystic dysplasia. Journal of Urology. 2004;172(4 Pt 2):1637-1639; discussion 1639.

Cain MP, Wu SD, Austin PF, Herndon CDA, Rink RC. Alpha blocker therapy for children with dysfunctional voiding and urinary retention. Journal of Urology. 2003;170:1514-1517.

Quayle SS, Coplen DE, Austin PF. The effect of health care coverage on circumcision rates among newborns. Journal of Urology. 2003;170:1533-1536; discussion 1536.

Austin PF, Casale AJ, Cain MP, Rink RC, Weintraub SJ. Lipopolysaccharide and inflammatory cytokines cause an inducible nitric oxide synthase-dependent bladder smooth muscle fibrotic response. Journal of Urology. 2003;170(2 Pt 1):645-648.

Homsy YL, Austin PF. Dysfunctional voiding syndromes and vesicoureteral reflux. Progress in Paediatric Urology. 2003;5:7-23.

Kropp BP, Colvert III JR, Cheng EY, Pope IV JC, Brock III JW, Adams MC, Austin PF, Furness III PD, Koyle MA. The use of small intestinal submucosa (SIS) as an “off the shelf” urethral sling material for pediatric urinary incontinence. Journal of Urology. 2002;168:1872-1876.

Brophy MM, Austin PF, Yan Y, Coplen DE. Vesicoureteral reflux and clinical outcomes in infants with prenatally detected hydronephrosis. Journal of Urology. 2002;168:1716-1719.

Austin PF, Siow Y, Fallat ME, Rink RC, Cain MP, Casale AJ. The relationship between müllerian inhibiting substance and androgens in boys with hypospadias. Journal of Urology. 2002;168:1784-1788.

Austin PF, Lockhart JL, Rink RC, Bissada NK, Hutcheson JC, Snyder HM. The multi-institutional experience with the gastrointestinal composite reservoir. Journal of Urology. 2001;165:2018-2021.

Austin PF, Westney OL, Leng WW, McGuire EJ, Ritchey ML. Advantages of rectus fascial slings for urinary incontinence in children with neuropathic bladders. Journal of Urology. 2001;165:2369-2371.

Cain MP, Rink RC, Thomas AC, Austin PF, Kaefer M, Casale AJ. Symptomatic ureteropelvic junction obstruction in children in the era of prenatal sonography – Is there a higher incidence of crossing vessels? Urology. 2001;57:338-341.

Austin PF, Ritchey ML. Dysfunctional voiding. Pediatrics in Review. 2000;21:336-341.

Austin PF, Rink RC, Cain MP. Nephrostomy tube drainage with pyeloplasty: Is it necessarily a bad choice? Journal of Urology. 2000;163:1528-1530.

Pub Med page for Paul F. Austin, M.D.

Books

Austin PF. Umbilical and Urachal Anomalies. In: Wilcox DT, Godbole PP and Koyle MA (eds.). Pediatric Urology: Surgical Complications and Management. Blackwell Publishing; 2007.

Austin PF, Coplen DE. Endoscopic Management of Ureterocele and Syringocele. In: Prasad Godbole (ed.). Pediatric Endourology Techniques. Springer Verlag; 2006.

Austin PF, Traxel EJ. Laboratory Assessment of the Pediatric Urologic Patient. In: Docimo SG, Canning DA and Khoury AE (eds.). Clinical Pediatric Urology. 5th Edition. 2006.

Austin PF, Homsy YL. Voiding Disorders in Girls. In: Carlin BI, Leong FC (eds.). Female Pelvic Health and Reconstructive Surgery. 1st ed. New York: Marcel Dekker, Inc.; 2003.

Homsy YL, Austin PF. Enuresis and Voiding Dysfunction. In: King LR, Belman AB, Kramer SA (eds). Clinical Pediatric Urology. 4th ed. Oxford: Isis Medical Media; 2001.

Casale AJ, Austin PF. Urologic Problems. In: Sanfilippo JS, Muram D, Lee PA, Dewhurst J (eds.). Pediatric and Adolescent Gynecology. 2nd ed. Philadelphia: W.B. Saunders Co.; 2001.

Homsy YL, Austin PF. Neuroblastoma. In: Graham SD, Glenn JF (eds.). Glenn’s Urologic Surgery. 5th ed. Philadelphia: Lippincott-Raven; 1998.

Editorial Positions

Reviewer for Scientific Journals
Journal of Urology, 1999-present
Urology, 2000-present
Journal of Endourology, 2001-present
Journal of Laparoendoscopic & Advanced Surgical Techniques, 2001-present
Neurourology and Urodynamics, 2004-present
Nephron, 2005–present
Cell Proliferation, 2006–present
Pediatrics, 2006–present
British Journal of Urology International 2007 - present