physician photo

Jeffrey M. Arbeit, MD

  • Professor of Surgery

Medical School

Medical Degree: Rush Medical College, Chicago, Illinois, 1976

Post Doctoral Education

Intern/Resident: University of Colorado, Denver, Colorado 1976-78

Clinical Associate: Surgery Branch, National Cancer Institute, Bethesda, Maryland 1978-81

Resident/Chief Resident: University of Colorado, Denver, Colorado, 1981-84

Surgical Oncology Fellow: Memorial Sloan Kettering Cancer Center, New York, N.Y. 1984-86
Sabbatical/Fellowship Transgenic Models of Multistage

Carcinogenesis: Doug Hanahan Lab, 1989-95

Honors and Awards

1975 Alpha Omega Alpha
1983 Ben Eiseman Surgical Research Award
1989 Who’s Who Young Americans
1993 Who’s Who in Science and Engineering
1996 Who’s Who in Science and Engineering
1999 Who’s Who in the World

Research Interests

The goal of my laboratory is to determine the molecular control of epithelial carcinogenesis and its modulation by genetic and epigenetic mechanisms. Currently, we are focusing on regulation of epithelial carcinogenic progression by hypoxic signaling, altered cellular redox potential, and sensing of changes in composition or levels of cellular nutrients. We are using transgenic and knockout mice to test the role of gain or loss of function of molecules regulating each of these processes to decipher their role in the progression of epithelial carcinogenesis. Ultimately we will use these models to discover additional putative novel molecular regulators of epithelial carcinogenic progression and control of angiogenesis. We will also use these models as platforms to validate novel antineoplastic or antiangiogenic therapies.

Funding

National Institutes of Health R01's; R01 CA90722-01 (2002-2007): R01 CA101012-01 (2003 - 2008)
CaP CURE Research Award (2001-02)

Selected Publications

Riley RR, Duensing S, Brake T, Münger K, Lambert PF, Arbeit JM. Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res. 2003 Aug 15;63(16):4862-71.

Li G, Gustafson-Brown C, Hanks SK, Nason K, Arbeit JM, Pogliano K, Wisdom RM, Johnson RS. c-Jun is essential for organization of the epidermal leading edge. Developmental Cell. 2003;4(6):865-877.

Arbeit JM. Mouse models of cervical cancer. Comparative Medicine. 2003;53(3):256-258.

Arbeit JM. Quiescent hypervascularity mediated by gain of HIF-1 alpha function. Cold Spring Harbor Symposia on Quantitative Biology. 2002;67:133-142.

Komuves LG, Michael E, Arbeit JM, Ma XK, Kwong A, Stelnicki E, Rozenfeld S, Morimune M, Yu QC, Largman C. HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation. Developmental Dynamics. 2002;224(1):58-68.

Elson DA, Thurston G, Huang LE, Ginzinger DG, McDonald DM, Johnson RS, Arbeit JM. Induction of hypervascularity without leak or inflammation in transgenic mice overexpressing hypoxia-inducible factor-á. Genes and Development. 2001;15:2520-2532.

Elson DA, Ryan HE, Snow JW, Johnson RS, Arbeit JM. Coordinate upregulation of HIF-1á and HIF-1 target genes during multistage epidermal carcinogenesis and wound healing. Cancer Research. 2000;60:6189-6195.

Ryan HE, Poloni M, McNulty W, Elson DA, Gassmann M, Arbeit JM, Johnson RS. Hypoxia-inducible factor-1á is a positive factor in solid tumor growth. Cancer Research. 2000;60:4010-4016.

Elson DA, Riley RR, Lacy A, Thordarson G, Talamantes FJ, Arbeit JM. Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis. Cancer Research. 2000;60:1267-1275.

Editorial Positions

1991-95 Associate Editor, Surgical Oncology
1995-98 Editorial Board, Surgical Oncology
1998-2002 Associate Editor, Annals of Surgical Oncology
2001-2002 Editorial Board, Cancer Biology and Therapy
1998-2002 Reviewer: Nature Genetics, American Journal of Pathology, Journal of Virology, Genes and Development, Cancer Research, PNAS, Surgery, Journal Clinical Investigation, Virology, Annals of Surgical Oncology, Molecular and Cellular Biology, Nature, Journal Cell Biology