physician photo

Scott Manson, PhD

  • Instructor of Urology

Graduate School

PhD, Molecular Biology, Washington University (St. Louis, MO), 1999-2007

Post Doctoral Education

Postdoctoral Fellowship, Urology, Washington University (St. Louis, MO), 2007-2013

Honors and Awards

2014: Young Investigator’s Award, National Kidney Foundation

2014: Finalist, Basic Science Research Prize, Fall Meeting of the Society for Pediatric Urology

2014: Travel Award, American Urological Association Summer Research Conference

2014: Basic Science Research Prize, Annual Meeting of the Society for Pediatric Urology/American Urological Association

2014: Travel Award, American Urological Association Annual Meeting

2013: Travel Award, American Society of Nephrology Annual Meeting

2013: Fellowship Award, National Kidney Foundation

2013: Basic Science Research Prize, Annual Meeting of the Society for Pediatric Urology/American Urological Association

2012: Travel Award / Selected Speaker, Annual Meeting of the Society of Basic Urologic Research

2011: Travel Award, American Society of Nephrology Annual Meeting

2011: Finalist, Basic Science Research Prize, Section on Urology, Annual Meeting of the American Academy of Pediatrics

2011: Selected Speaker, Washington University Postdoctoral Scientific Symposium

2010: Travel Award, American Society of Nephrology Annual Meeting

2009: Basic Science Research Prize, Section on Urology, Annual Meeting of the American Academy of Pediatrics
  

Research Interests

  • The Pathogenesis and Treatment of Renal Injuries Resulting From Urinary Obstruction (Funded)
  • The Molecular Mechanisms Underlying Fibroblast Activation in Renal Fibrosis (Funded)
  • The Biochemical Basis of the Interactions between Proteins and Calcium Oxalate Crystals During the Development of Kidney Stones (Unfunded/Seeking Funding)


Selected Publications

Manson SR, Guo Q, Austin PF. The critical roles of BMP-7 in kidney development, the responses to renal injury, and chronic kidney disease.  Vitamins and Hormones (accepted, in press).

Manson SR, Song JB, Hruska KA, Liapis HT, Austin PF. The loss of Bmp‐7 expression contributes to the progression of kidney disease in patients with obstructive uropathies. The Journal of Urology (accepted, in press).

Guo Q, Tripathy P, Hoshi M, Manson SR, Austin PF, Jain S, Bates C, Chen F. Transcriptional dysregulation in the ureteric bud causes multicystic dysplastic kidney by branching morphogenesis defect. The Journal of Urology (electronically published ahead of print).

Manson SR, Hruska KA, Austin PF. The HDAC‐dependent suppression of Bmp‐7 transcription contributes to the pathogenesis of renal injury in obstructive uropathies. The Journal of Urology  2014;191(1): 242‐52. [PMID: 23820056]

Dho SH, Deverman BE, Lapid C, Manson SR, Gan L, Riehm JJ, Aurora R, Kwon KS, Weintraub SJ. Control of cellular Bcl‐xL levels by deamidation‐regulated degradation. PLOS Biology 2013;11(6): e1001588. [PMID: 23823868]

Manson SR. Editorial comment. The Journal of Urology 2013;190(4 Suppl): 1602. [PMID: 23792000]

Manson SR, Niederhoff RA, Hruska KA, Austin PF. Endogenous BMP‐7 is a critical molecular determinant of the reversibility of obstruction‐induced renal injuries. American Journal of Physiology ‐ Renal Physiology 2011;301(6): F1293‐302. [PMID: 21880836]

Manson SR, Niederhoff RA, Hruska KA, Austin PF. The BMP‐7‐Smad1/5/8 pathway promotes the repair of the kidney after obstruction‐induced renal injury. The Journal of Urology 2011;185: 2523‐30. [PMID: 21527199]

Niederhoff RA, Manson SR, Tawfik A, Austin PF. The physiological significance of p27(KIP1) expression in detrusor function. The Journal of Urology 2010;184(4 Suppl): 1686‐91. [PMID: 20728136]

Jiang X, Austin PF, Niederhoff RA, Manson SR, Riehm JJ, Cook BL, Pengue G, Chitaley K, Nakayama K, Nakayama KI, Weintraub SJ. Mechanoregulation of proliferation. Molecular and Cellular Biology 2009;29(18): 5104‐14. [PMID: 19596792]

Henderson CC, Zhang Z, Manson SR, Riehm JJ, Kataoka M, Flye MW, Garbow JR, You M, Weintraub SJ. A moderate reduction of Bcl‐x(L) expression protects against tumorigenesis; however, it also increases susceptibility to tissue injury. Oncogene 2005;24(47): 7120‐4. [PMID: 16007126]

Weintraub SJ, Manson SR. Asparagine deamidation: a regulatory hourglass. Mechanisms of Ageing and Development 2004;125(4): 255‐7 (5(1): 3‐4. [PMID: 14749119]

Austin PF, Cook BL, Niederhoff RA, Manson SR, Coplen DE, Weintraub SJ. Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin. The Journal of Urology 2004;172(4): 1662‐5. [PMID: 15371785]

Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosova I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, Weintraub SJ. Bcl‐xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell 2002;111(1): 51‐62. [PMID: 12372300]

Godbout JP, Pesavento J, Hartman ME, Manson SR, Freund GG. Methylglyoxal enhances cisplatin‐induced cytotoxicity by activating protein kinase C delta. The Journal of Biological Chemistry 2002;277(4): 2554‐61. [PMID: 11707430]

PubMed page for Scott Manson, PhD

Editorial Positions

2011-present: Peer Reviewer, The Journal of Urology

2013-present: Peer Reviewer, Journal of Pediatric Urology

2011-present: Peer Reviewer, Yale Journal of Biology and Medicine

2011-present: Peer Reviewer, Nephrology Reviews